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KMID : 0923620130130050184
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Immune Network
2013 Volume.13 No. 5 p.184 ~ p.193
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Emerging Co-signaling Networks in T Cell Immune Regulation
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Jung Keun-Ok
Choi In-Hak
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Abstract
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Co-signaling molecules are surface glycoproteins that pos-itively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell re-ceptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the under-standing of underlying mechanisms of the immune modu-lation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of au-toimmune diseases and cancers. In this review, we briefly de-scribe the characteristics of well-known B7 co-signaling fam-ily members regarding the expression, functions and ther-apeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.
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KEYWORD
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Co-signaling molecule, B7 family, Co-stimulation, Co-inhibition
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